SELECTIVE-INHIBITION BY 4-HYDROXYNONENAL OF SPHINGOSINE-STIMULATED PHOSPHOLIPASE-D IN NIH-3T3 CELLS

被引：8

作者：

KISS, Z

CRILLY, KS

ROSSI, MA

ANDERSON, WB

机构：

[1] UNIV TURIN,GEN PATHOL SECT,DEPT EXPTL MED & ONCOL,I-10124 TURIN,ITALY

[2] NCI,CELLULAR ONCOL LAB,BETHESDA,MD 20892

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1124卷 / 03期

关键词：

SPHINGOSINE; 4-HYDROXYNONENAL; PHOSPHOLIPASE-D; PHOSPHOLIPID HYDROLYSIS;

D O I：

10.1016/0005-2760(92)90143-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In fibroblasts, the mitogenic effects of sphingosine involves a rapid rise in the cellular content of phosphatidic acid (PtdOH) which may be due to the stimulation of phospholipase D, or inhibition of PtdOH phosphohydrolase, or both. Here, we demonstrate that in fibroblasts, 4-hydroxynonenal is a selective inhibitor of sphingosine-stimulated phospholipid hydrolysis, and it also inhibits sphingosine-induced formation of PtdOH.

引用

页码：300 / 302

页数：3

共 20 条

[1] ANALYSIS OF THE WATER-SOLUBLE PRODUCTS OF PHOSPHATIDYLCHOLINE BREAKDOWN BY ION-EXCHANGE CHROMATOGRAPHY - BOMBESIN AND TPA (12-ORTHO-TETRADECANOYLPHORBOL 13-ACETATE) STIMULATE CHOLINE GENERATION IN SWISS 3T3 CELLS BY A COMMON MECHANISM [J].