EXPERIMENTAL VACCINE PROTECTION AGAINST HOMOLOGOUS AND HETEROLOGOUS STRAINS OF FELINE IMMUNODEFICIENCY VIRUS

被引：98

作者：

YAMAMOTO, JK

HOHDATSU, T

OLMSTED, RA

PU, R

LOUIE, H

ZOCHLINSKI, HA

ACEVEDO, V

JOHNSON, HM

SOULDS, GA

GARDNER, MB

机构：

[1] UNIV CALIF DAVIS,SCH MED,DEPT MED PATHOL,DAVIS,CA 95616

[2] KITASATO UNIV,SCH VET MED & ANIM SCI,DEPT VET INFECT DIS,ADMORI 034,JAPAN

[3] UNIV FLORIDA,DEPT MICROBIOL & CELL SCI,GAINESVILLE,FL 32611

[4] GEORGETOWN UNIV,DEPT MICROBIOL,DIV MOLEC VIROL & IMMUNOL,ROCKVILLE,MD 20852

[5] SYNBIOT CORP,SAN DIEGO,CA 92127

来源：

JOURNAL OF VIROLOGY | 1993年 / 67卷 / 01期

关键词：

D O I：

10.1128/JVI.67.1.601-605.1993

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

More than 90% of cats immunized with inactivated whole infected-cell or cell-free feline immunodeficiency virus (FIV) vaccines were protected against intraperitoneal infection with 10 50% animal infectious doses of either homologous FIV Petaluma (28 of 30 cats) or heterologous FIV Dixon strain (27 of 28 cats). All 15 control cats were readily infected with either strain of FIV. Protection appears to correlate with antiviral envelope antibody levels by a mechanism yet to be determined.

引用

页码：601 / 605

页数：5

共 22 条

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