GERMLINE REARRANGEMENT OF MCC AND APC DETECTED BY PULSED-FIELD GEL-ELECTROPHORESIS AND FLUORESCENT IN-SITU HYBRIDIZATION

被引：11

作者：

GAYTHER, S

WELLS, D

GULATI, K

CHAPMAN, P

BURN, J

DELHANTY, JDA

机构：

[1] UNIV LONDON UNIV COLL,DEPT GENET & BIOMETRY,GALTON LAB,4 STEPHENSON WAY,LONDON NW1 2HE,ENGLAND

[2] UNIV NEWCASTLE UPON TYNE,NO REG POLYPOSIS REGISTRY,DIV HUMAN GENET,NEWCASTLE TYNE NE2 4AA,ENGLAND

来源：

ANNALS OF HUMAN GENETICS | 1993年 / 57卷

关键词：

D O I：

10.1111/j.1469-1809.1993.tb01592.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Pulsed field gel electrophoresis was carried out on lymphocyte DNA obtained from ten patients with the inherited premalignant condition adenomatous polyposis coli and a similar number of control samples to search for large scale molecular rearrangements in the vicinity of the APC locus. DNA from one patient showed a rearranged pattern which was interpreted as evidence for an inversion of approximately 150 kb, changing the transcriptional orientation of the neighbouring MCC gene and bringing it closer to APC. Such an interpretation was supported by fluorescent in situ hybridization data.

引用

页码：169 / &

共 25 条

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