ENHANCEMENT OF NITRIC-OXIDE PRODUCTION FROM ACTIVATED MACROPHAGES BY A PURIFIED FORM OF GINSENOSIDE (RG1)

被引：25

作者：

FAN, ZH ^{[1
]}

ISOBE, KI ^{[1
]}

KIUCHI, K ^{[1
]}

NAKASHIMA, I ^{[1
]}

机构：

[1] NAGOYA UNIV,SCH MED,DEPT IMMUNOL,SHOWA KU,NAGOYA,AICHI 466,JAPAN

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 1995年 / 23卷 / 3-4期

关键词：

D O I：

10.1142/S0192415X9500033X

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

We studied the actions of purified ginsenosides Rg1 and Rb1 on nitric oxide production from macrophages and a macrophage cell line RAW264-7. Although neither Rg1 nor Rbl induced nitric oxide from resting macrophages, Rg1 enhanced the production of nitric oxide from IFN-gamma activated-macrophages or RAW cells. Rg1 also enhanced the production of nitric oxide from macrophages cocultured with nonadherent spleen cells stimulated by conA, LPS or anti-CD3. Rb1, however, did not significantly enhance nitric oxide production from stimulated macrophages or RAW cells. Rg1 enhanced the tumor cell killing by nitric oxide produced from IFN-gamma-activated macrophages.

引用

页码：279 / 287

页数：9