INVOLVEMENT OF PROTEIN KINASE-C IN THE REGULATION OF ASSEMBLY-DISASSEMBLY OF NEUROFILAMENTS INVITRO

被引：84

作者：

GONDA, Y

NISHIZAWA, K

ANDO, S

KITAMURA, S

MINOURA, Y

NISHI, Y

INAGAKI, M

机构：

[1] AICHI CANC CTR,RES INST,EXPTL RADIOL LAB,CHIKUSA KU,NAGOYA,AICHI 464,JAPAN

[2] AICHI CANC CTR,RES INST,BIOPHYS UNIT,CHIKUSA KU,NAGOYA,AICHI 464,JAPAN

[3] LIFE INFORMAT ANAL CTR,KOMAKI 485,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 167卷 / 03期

基金：

日本科学技术振兴机构;

关键词：

D O I：

10.1016/0006-291X(90)90667-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein kinase C phosphorylated the major mammalian neurofilament protein (NF-L) with ∼3 mol phosphate per mol protein. The phosphorylated NF-L no longer formed the filaments. Sequential analysis of the tryptic phosphopeptides, together with the known primary sequence, revealed that Ser-12, Ser-27, Ser-33 and Ser-51 were phosphorylated by protein kinase C. These findings contribute toward elucidation of mechanisms regulating the functions of neurofilaments. © 1990.

引用

页码：1316 / 1325

页数：10

共 28 条

[1] NEUROFILAMENTS FROM MAMMALIAN CENTRAL AND PERIPHERAL-NERVE SHARE CERTAIN POLYPEPTIDES [J].