CLEARANCE OF VANCOMYCIN DURING CONTINUOUS ARTERIOVENOUS HEMODIAFILTRATION

被引：24

作者：

BELLOMO, R ^{[1
]}

ERNEST, D ^{[1
]}

PARKIN, G ^{[1
]}

BOYCE, N ^{[1
]}

机构：

[1] PRINCE HENRY HOSP,MONASH MED CTR,DEPT MED,ST KILDA RD,MELBOURNE,VIC 3004,AUSTRALIA

来源：

CRITICAL CARE MEDICINE | 1990年 / 18卷 / 02期

关键词：

D O I：

10.1097/00003246-199002000-00011

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The clearance of vancomycin during therapy with continuous arteriovenous hemodiafiltration (CAVHD) has been measured in vivo. Vancomycin clearances (n = 16) were 0.636 ± 0.269 L/h (10.5 ± 4.46 ml/min). Effective drug clearances were proportional to ultrafiltrate volumes, reflecting convective clearance. Clearances of vancomycin on CAVHD were approximately twice the values seen with continuous arteriovenous hemofiltration. These data allow construction of a dosing schedule for vancomycin therapy in patients receiving renal support via CAVHD.

引用

页码：181 / 183

页数：3

共 11 条

[1]

ACHERMAN BH, 1988, DRUG INTELL CLIN PHA, V22, P300

[2]

CHEUNG RPF, 1986, PHARMACOTHERAPY, V6, P153

[3] PHARMACOKINETIC DATA AND DRUG MONITORING .1. ANTIBIOTICS AND ANTIARRHYTHMICS [J].

CHOW, MSS ;

RONFELD, RA .

JOURNAL OF CLINICAL PHARMACOLOGY, 1975, 15 (5-6) :405-418

[4]

GERONEMUS R, 1984, T AM SOC ART INT ORG, V30, P610

[5]

KOGSTAD DJ, 1980, J CLIN PHARMACOL, V20, P197

[6]

LAU AH, 1987, T AM SOC ART INT ORG, V23, P772

[7] PERSISTENCE OF VANCOMYCIN IN BLOOD DURING RENAL FAILURE AND ITS TREATMENT BY HEMODIALYSIS [J].

LINDHOLM, DD ;

MURRAY, JS .

NEW ENGLAND JOURNAL OF MEDICINE, 1966, 274 (19) :1047-&

[8]

MATZKE GR, 1985, CLIN PHARMACY, V4, P311

[9]

MATZKE GR, 1986, CLIN PHARMACOL THER, P425

[10]

NIELSEN HE, 1975, ACTA MED SCAND, V197, P261

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