SYNTHESIS OF A TRI-PHOSPHORYLATED PEPTIDE CORRESPONDING TO THE MAJOR AUTOPHOSPHORYLATION SITE IN THE INSULIN-RECEPTOR - CONFORMATIONAL COMPARISON WITH ITS NONPHOSPHORYLATED ANALOG

被引：5

作者：

CHAVANIEU, A ^{[1
]}

NAHARISOA, H ^{[1
]}

HEITZ, F ^{[1
]}

CALAS, B ^{[1
]}

GRIGORESCU, F ^{[1
]}

机构：

[1] CNRS,PHYSICOCHIM SYST POLYPHASES LAB,CNRS,URA 330,F-34033 MONTPELLIER,FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(01)80812-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Using FmocTyrO(PO3Bzl2)OH, we synthesized and purified a triphosphosphorylated peptide corresponding to the major autophosphorylation site of the insulin receptor. By CD spectroscopy, conformational comparison of the phosphorylated peptide with its non-phosphorylated analogue showed a rigidification of the peptide backbone when the aromatic side chains bear negatively charged groups.

引用

页码：299 / 302

页数：4

共 10 条

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