THE VOLTAGE-GATED NONSELECTIVE CATION CHANNEL FROM HUMAN RED-CELLS IS SENSITIVE TO ACETYLCHOLINE

被引：49

作者：

BENNEKOU, P

机构：

[1] August Krogh Institute, University of Copenhagen, Copenhagen

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1147卷 / 01期

关键词：

ERYTHROCYTE; CATION CHANNEL; ACETYLCHOLINE RECEPTOR; CARBACHOL; NICOTINE; PATCH CLAMP;

D O I：

10.1016/0005-2736(93)90328-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using patch-clamp technique it is demonstrated, that the voltage-gated non-selective cation channel present in the human red cell is coupled to an acetylcholine receptor of nicotinic type. The concentration dependence of carbachol, the potency of selected agonists and an estimate of the numbers of channels/red cell are reported.

引用

页码：165 / 167

页数：3

共 14 条

[1]

AROMSTAM RS, 1977, LIFE SCI, V20, P1175

[2]

BENNEKOU P, 1991, ACTA PHYSL SCAND, V143, P1

[3] EVIDENCE FOR A VOLTAGE-GATED, NONSELECTIVE CATION CHANNEL IN THE HUMAN RED-CELL MEMBRANE [J].