PROGESTERONE INCREASES THE PRODUCTION OF TISSUE INHIBITOR OF METALLOPROTEINASES-2 IN RABBIT UTERINE CERVICAL FIBROBLASTS

被引：21

作者：

IMADA, K

ITO, A

ITOH, Y

NAGASE, H

MORI, Y

机构：

[1] TOKYO COLL PHARM,DEPT BIOCHEM,HACHIOJI,TOKYO 19203,JAPAN

[2] UNIV KANSAS,MED CTR,DEPT BIOCHEM & MOLEC BIOL,KANSAS CITY,KS 66160

来源：

FEBS LETTERS | 1994年 / 341卷 / 01期

关键词：

PROGESTERONE; TIMP-2; GELATINASE A; MATRIX METALLOPROTEINASE; UTERINE CERVIX;

D O I：

10.1016/0014-5793(94)80250-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rabbit uterine cervical fibroblasts in culture produces tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2. When cells were treated with physiological concentrations of progesterone, the production of two TIMPs increased, and essentially all TIMP-2 was found to be complexed with promatrix metalloproteinase 2 (proMMP-2)/progelatinase A. Progesterone did not modulate the production of proMMP-2 and resulted in the increased total amount of proMMP-2-TIMP-2 complex. These observations provide the first evidence that progesterone participates in maintaining the homeostasis of connective tissue matrix in uterine cervix by augmenting both TIMP-1 and TIMP-2 production along with the known suppressive effects on the proMMP-1 and proMMP-3 production.

引用

页码：109 / 112

页数：4

共 23 条

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[2]

GOLDBERG GI, 1992, J BIOL CHEM, V267, P4583

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