DEHYDROEPIANDROSTERONE - THE MISSING LINK BETWEEN HYPERINSULINEMIA AND ATHEROSCLEROSIS

被引：106

作者：

NESTLER, JE

CLORE, JN

BLACKARD, WG

机构：

[1] Division of Endocrinology/Metabolism, Medical College of Virginia, Box 111, Richmond

来源：

FASEB JOURNAL | 1992年 / 6卷 / 12期

关键词：

DEHYDROEPIANDROSTERONE; INSULIN; ATHEROSCLEROSIS; AGING; OBESITY;

D O I：

10.1096/fasebj.6.12.1387859

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A well-established epidemiologic association exists between hyperinsulinemia and macrovascular disease. However, the mechanism or mechanisms by which hyperinsulinemia promotes atherogenesis is unknown. Recent evidence indicates that the adrenal steroid dehydroepiandrosterone (DHEA) exerts multiple antiatherogenic effects and also suggests that hyperinsulinemia may reduce serum DHEA and DHEA-sulfate levels by decreasing production and enhancing metabolic clearance. We advance the hypothesis that hyperinsulinemia promotes macrovascular disease in part by reducing serum DHEA and DHEA-sulfate levels and illustrate how this may be the case in two clinical conditions characterized by hyperinsulinemic insulin resistance: aging and obesity.

引用

收藏

页码：3073 / 3075

页数：3

相关论文

共 53 条

[1] PLASMA-LIPIDS AND STEROID-HORMONES IN PATIENTS WITH HYPERCHOLESTEROLEMIA OR HYPERLIPEMIA DURING DEHYDROEPIANDROSTERONE SULFATE ADMINISTRATION [J].

ADLERCREUTZ, H ;

SCHAUMANN, KO ;

SVANBORG, A ;

VIHKO, R ;

KERSTELL, J .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1972, 2 (02) :91-+

[2] DEHYDROEPIANDROSTERONE FEEDING PREVENTS AORTIC FATTY STREAK FORMATION AND CHOLESTEROL ACCUMULATION IN CHOLESTEROL-FED RABBIT [J].

ARAD, Y ;

BADIMON, JJ ;

BADIMON, L ;

HEMBREE, WC ;

GINSBERG, HN .

ARTERIOSCLEROSIS, 1989, 9 (02) :159-166

[3] A PROSPECTIVE-STUDY OF DEHYDROEPIANDROSTERONE SULFATE, MORTALITY, AND CARDIOVASCULAR-DISEASE [J].

BARRETTCONNOR, E ;

KHAW, KT ;

YEN, SSC .

NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (24) :1519-1524

[4]

BENDAVID M, 1967, P SOC EXP BIOL MED, V125, P1136

[5] PATTERN OF PLASMA-LEVELS OF CORTISOL, DEHYDROEPIANDROSTERONE AND PREGNENOLONE SULFATE IN NORMAL SUBJECTS AND IN PATIENTS WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA DURING ACTH INFUSION [J].

BOIZEL, R ;

DEPERETTI, E ;

CATHIARD, AM ;

HALIMI, S ;

BOST, M ;

BERTHEZENE, F ;

SAEZ, JM .

CLINICAL ENDOCRINOLOGY, 1986, 25 (04) :363-371

[6] INSULIN RESISTANCE - A MULTIFACETED SYNDROME RESPONSIBLE FOR NIDDM, OBESITY, HYPERTENSION, DYSLIPIDEMIA, AND ATHEROSCLEROTIC CARDIOVASCULAR-DISEASE [J].

DEFRONZO, RA ;

FERRANNINI, E .

DIABETES CARE, 1991, 14 (03) :173-194

[7] EFFECT OF ACUTE PHYSIOLOGICAL ELEVATIONS OF INSULIN ON CIRCULATING ANDROGEN LEVELS IN NONOBESE WOMEN [J].

DIAMOND, MP ;

GRAINGER, DA ;

LAUDANO, AJ ;

STARICKZYCH, K ;

DEFRONZO, RA .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 72 (04) :883-887

[8]

EICH DM, 1990, CLIN RES, V38, pA2

[9] CORRELATIONS OF BASAL ESTROGENS WITH ADRENAL ANDROGENS AND RELATIVE WEIGHT IN NORMAL WOMEN [J].

ELLISON, PT .

ANNALS OF HUMAN BIOLOGY, 1984, 11 (04) :327-336

[10] RELATIONSHIP OF ANDROGENIC ACTIVITY TO BODY-FAT TOPOGRAPHY, FAT-CELL MORPHOLOGY, AND METABOLIC ABERRATIONS IN PREMENOPAUSAL WOMEN [J].

EVANS, DJ ;

HOFFMANN, RG ;

KALKHOFF, RK ;

KISSEBAH, AH .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1983, 57 (02) :304-310

← 1 2 3 4 5 6 →