MINERALOCORTICOID REPLACEMENT IN ADDISONS-DISEASE

被引：26

作者：

THOMPSON, DG ^{[1
]}

MASON, AS ^{[1
]}

GOODWIN, FJ ^{[1
]}

机构：

[1] LONDON HOSP, DEPT METAB & ENDOCRINOL, LONDON E1 1BB, ENGLAND

来源：

CLINICAL ENDOCRINOLOGY | 1979年 / 10卷 / 05期

关键词：

D O I：

10.1111/j.1365-2265.1979.tb02107.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Eight patients with treated Addison's disease were studied whilst receiving different doses of fludrocortisone together with a constant intake of glucocorticoid. Plasma renin activity (PRA), blood pressure, pulse rate and plasma potassium and urea concentrations were measured after 2‐week periods on each dose. In two patients, PRA measurements indicated that mineralocorticoid replacement therapy had been inadequate. In four others, PRA remained normal throughout the study, even after fludrocortisone had been discontinued, suggesting that the drug was unnecessary for the maintenance of normal sodium balance in these patients. Asymptomatic fludrocortisone overdosage was indicated by a low plasma potassium concentration, but not by PRA measurements which failed in this study to distinguish between adequate and excessive mineralocorticoid replacement. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：499 / 506

页数：8

共 11 条

[1]

BROWN JJ, 1963, LANCET, V2, P278

[2]

BROWN JJ, 1968, Q J MED, V37, P97

[3]

CONN JW, 1964, JAMA-J AM MED ASSOC, V190, P213

[4] NORMOKALEMIC PRIMARY ALDOSTERONISM - A DETECTABLE CAUSE OF CURABLE ESSENTIAL HYPERTENSION [J].

CONN, JW ;

COHEN, EL ;

ROVNER, DR ;

NESBIT, RM .

JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1965, 193 (03) :200-&

[5] SPIRONOLACTONE-INDUCED INHIBITION OF ALDOSTERONE BIOSYNTHESIS IN PRIMARY ALDOSTERONISM - MORPHOLOGICAL AND FUNCTIONAL STUDIES [J].

CONN, JW ;

HINERMAN, DL .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1977, 26 (12) :1293-1307

[6]

GOODMAN LS, 1975, PHARMACOL BASIS, P1491

[7]

LEDINGHAM JG, 1967, CIRC RES, V21, pI177

[8] EFFECT OF METHYLDOPA ON PLASMA RENIN ACTIVITY IN MAN [J].

MOHAMMED, S ;

FASOLA, AF ;

PRIVITERA, PJ ;

LIPICKY, RJ ;

MARTZ, BL ;

GAFFNEY, TE .

CIRCULATION RESEARCH, 1969, 25 (05) :543-+

[9] EFFECT OF CORTICOTROPIN ON ALDOSTERONE EXCRETION AND PLASMA RENIN IN NORMAL SUBJECTS IN ESSENTIAL HYPERTENSION AND IN PRIMARY ALDOSTERONISM [J].

NEWTON, MA ;

LARAGH, JH .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1968, 28 (07) :1006-+

[10] SEARCHING OUT LOW RENIN PATIENTS - LIMITATIONS OF SOME COMMONLY USED METHODS [J].

SEALEY, JE ;

LARAGH, JH .

AMERICAN JOURNAL OF MEDICINE, 1973, 55 (03) :303-314

← 1 2 →