ABSOLUTE BIOAVAILABILITY OF NICOTINE APPLIED TO DIFFERENT NASAL REGIONS

被引：43

作者：

JOHANSSON, CJ ^{[1
]}

OLSSON, P ^{[1
]}

BENDE, M ^{[1
]}

CARLSSON, T ^{[1
]}

GUNNARSSON, PO ^{[1
]}

机构：

[1] KARNSJUKHUSET,DEPT EAR NOSE THROAT,SKOVDE,SWEDEN

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1991年 / 41卷 / 06期

关键词：

NICOTINE; BIOAVAILABILITY; NASAL SPRAY;

D O I：

10.1007/BF00314989

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The absolute bioavailability of nicotine administered nasally, as drops to the nasal conchae and nasal septum, and as a nasal spray, has been studied in eight healthy volunteers. Single nasal doses of 1 mg nicotine were given and plasma concentrations of nicotine were followed for 6 h. Compared to an intravenous infusion of nicotine, the bioavailability of the nasal administrations was 60 to 75%. The rate of absorption was fast, the maximum concentration being reached after about 10 min. In the present study, there was no significant difference in the rate or extent of absorption between the different nasal treatments.

引用

页码：585 / 588

页数：4

共 14 条

[1]

BENOWITZ NL, 1982, J PHARMACOL EXP THER, V221, P368

[2] DAILY INTAKE OF NICOTINE DURING CIGARETTE-SMOKING [J].