THE POTENTIAL USE OF A DOPAMINE NEURON ANTIBODY AND A STRIATAL-DERIVED NEUROTROPHIC FACTOR AS DIAGNOSTIC MARKERS IN PARKINSONS-DISEASE

被引:48
作者
CARVEY, PM
MCRAE, A
LINT, TF
PTAK, LR
LO, ES
GOETZ, CG
KLAWANS, HL
机构
[1] RUSH PRESBYTERIAN ST LUKES MED CTR, DEPT NEUROL SCI, CHICAGO, IL 60612 USA
[2] RUSH PRESBYTERIAN ST LUKES MED CTR, DEPT PHARMACOL, CHICAGO, IL 60612 USA
[3] GOTHENBURG UNIV, NEUROSCI RES CTR, INST NEUROBIOL, S-41124 GOTHENBURG, SWEDEN
[4] RUSH PRESBYTERIAN ST LUKES MED CTR, DEPT IMMUNOL MICROBIOL, CHICAGO, IL 60612 USA
关键词
D O I
10.1212/WNL.41.5_Suppl_2.53
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The cerebral spinal fluid (CSF) of patients with Parkinson's disease (PD) contains an antibody that immunocytochemically reacts with dopamine (DA) neurons in the substantia nigra (SN). This antibody was found in 78% of the CSF samples taken from patients with clinical PD. In contrast, only 3% of the CSF samples taken from control patients or patients with neurologic symptoms other than PD possessed this antibody. The production of this antibody might contribute to disease progression but does not appear to be the etiologic factor responsible for PD. In other experiments, concentrates of the CSF of patients with PD enhanced growth of mesencephalic cultures relative to control CSF. Both the antibody and the growth-promoting activity found in CSF are associated with degeneration of the SN and might therefore be useful as potential diagnostic markers for PD.
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页码:53 / 60
页数:8
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