EFFECTS OF INTRAVENOUS COCAINE ON REPRODUCTIVE FUNCTION IN THE MATED RABBIT

被引：13

作者：

ATLAS, SJ ^{[1
]}

WALLACH, EE ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT GYNECOL & OBSTET,BALTIMORE,MD 21205

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1991年 / 165卷 / 06期

关键词：

COCAINE; RABBIT; OVULATION; IMPLANTATION; PREGNANCY;

D O I：

10.1016/0002-9378(91)90033-N

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

A dramatic increase in the use of crack cocaine by young women has resulted in the exposure of a substantial number of fetuses to the drug in utero. The goal of these experiments was to investigate the effects of intravenous cocaine (a model for crack) on reproductive function in the female rabbit. We used two protocols: (1) single daily injections over the course of pregnancy ("single daily" protocol), with animals examined on day 1, 8, 15, 22, or 29, and (2) six hourly injections on the day of mating ("binge" protocol). The maximum tolerated dose of cocaine, 4 mg/kg, was administered at 0.5 ml/min. The single daily protocol increased ovulation but had no effect on fetal and placental weights or preterm delivery. The binge protocol significantly reduced in vitro development of retrieved embryos but did not affect implantation assessed on day 8 of pregnancy.

引用

页码：1785 / 1790

页数：6

共 23 条

[1] TOXICITY ASSOCIATED WITH LONG-TERM INTRAVENOUS HEROIN AND COCAINE SELF-ADMINISTRATION IN THE RAT [J].

BOZARTH, MA ;

WISE, RA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1985, 254 (01) :81-83

[2]

CHERUKURI R, 1988, OBSTET GYNECOL, V72, P147

[3]

CHOUTEAU M, 1988, OBSTET GYNECOL, V72, P351

[4] DOSE-DEPENDENT CONSEQUENCES OF COCAINE ON PREGNANCY OUTCOME IN THE LONG-EVANS RAT [J].

CHURCH, MW ;

DINTCHEFF, BA ;

GESSNER, PK .

NEUROTOXICOLOGY AND TERATOLOGY, 1988, 10 (01) :51-58

[5] PRENATAL COCAINE EXPOSURE IN THE LONG-EVANS RAT .1. DOSE-DEPENDENT EFFECTS ON GESTATION, MORTALITY, AND POSTNATAL MATURATION [J].

CHURCH, MW ;

OVERBECK, GW ;

ANDRZEJCZAK, AL .

NEUROTOXICOLOGY AND TERATOLOGY, 1990, 12 (04) :327-334

[6] PROGESTERONE SECRETION BY CORPORA-LUTEA OF THE ISOLATED PERFUSED RABBIT OVARY DURING PSEUDOPREGNANCY [J].

DHARMARAJAN, AM ;

YOSHIMURA, Y ;

SUEOKA, K ;

ATLAS, SJ ;

DUBIN, NH ;

EWING, LL ;

ZIRKIN, BR ;

WALLACH, EE .

BIOLOGY OF REPRODUCTION, 1988, 38 (05) :1137-1143

[7] THE TERATOGENICITY OF COCAINE [J].

FANTEL, AG ;

MACPHAIL, BJ .

TERATOLOGY, 1982, 26 (01) :17-19

[8] PRELIMINARY EVIDENCE FOR A COCAINE-INDUCED EMBRYOPATHY IN MICE [J].

FINNELL, RH ;

TOLOYAN, S ;

VANWAES, M ;

KALIVAS, PW .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1990, 103 (02) :228-237

[9] TRANSAMNIOTIC FETAL FEEDING .2. A MODEL OF INTRAUTERINE GROWTH-RETARDATION USING THE RELATIONSHIP OF NATURAL RUNTING TO UTERINE POSITION [J].

FLAKE, AW ;

VILLA, RL ;

ADZICK, NS ;

HARRISON, MR .

JOURNAL OF PEDIATRIC SURGERY, 1987, 22 (09) :816-819

[10]

Hafez E., 1970, RABBITS REPROD BREED, P273

← 1 2 3 →