MODULATION OF GLIAL-CELL DIFFERENTIATION BY EXPOSURE TO LEAD AND CADMIUM

被引：21

作者：

STARK, M

WOLFF, JEA

KORBMACHER, A

机构：

[1] UNIV DUSSELDORF,MED INST ENVIRONM HYG,W-4000 DUSSELDORF 1,GERMANY

[2] UNIV DUSSELDORF,DEPT NEUROPATHOL,W-4000 DUSSELDORF 1,GERMANY

来源：

NEUROTOXICOLOGY AND TERATOLOGY | 1992年 / 14卷 / 04期

关键词：

PB; CD; HEAVY METALS; GLIOMA CELLS; CELL CULTURE; DIFFERENTIATION; INVITRO; NERVOUS SYSTEM; NEUROTOXICITY; GLIAL FIBRILLARY ACIDIC PROTEIN; S100; TRANSFERRIN RECEPTOR;

D O I：

10.1016/0892-0362(92)90003-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The influence of the neurotoxic agents lead and cadmium on human glioma cells (86HG-39, 87HG-31, 88HG-14, and A172) and rat glioma cells (F98 and RG2) was investigated in vitro by means of immunocytochemistry and growth data. Both heavy metals increased the growth rate, decreased the expression of differentiation markers (glial fibrillary acidic protein, S100 protein), and increased the expression of the malignancy marker transferrin receptor. The results indicate a decrease in the level of differentiation and impairment of glial cell function. Consequently, the neurotoxicity of Pb and Cd may be attributed to direct action not only on neurons but also on glial cells necessary for neuronal function. Possible molecular mechanisms are discussed.

引用

页码：247 / 252

页数：6

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[1] FATE OF CD109 IN MOUSE - AN AUTORADIOGRAPHIC STUDY AFTER A SINGLE INTRAVENOUS-INJECTION OF CD109CL2 [J].