RODENT TISSUE DISTRIBUTION OF 2-CYANOETHYLENE OXIDE, THE EPOXIDE METABOLITE OF ACRYLONITRILE

被引：12

作者：

KEDDERIS, GL

BATRA, R

HELD, SD

LOOS, MA

TEO, SKO

机构：

[1] Chemical Industry Institute of Toxicology, Research Triangle Park, NCUSA

来源：

TOXICOLOGY LETTERS | 1993年 / 69卷 / 01期

关键词：

2-CYANOETHYLENE OXIDE; ACRYLONITRILE; TISSUE DISTRIBUTION;

D O I：

10.1016/0378-4274(93)90141-J

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The direct acting mutagen 2-cyanoethylene oxide (CEO), formed in the liver by oxidation of acrylonitrile (ACN), is thought to mediate the extrahepatic carcinogenic effects of ACN in rats. This study determined the tissue distribution of CEO (3 mg/kg p.o.) in F-344 rats and B6C3F1 mice. Radioactivity from [2,3-C-14]CEO was widely distributed in the major organs of rodents by 2 h and decreased by 71% to 90% within 24 h, demonstrating that there was no preferential tissue uptake or retention of CEO. CEO was detected in rodent blood and brain 5-10 min after an oral dose of ACN (10 mg/kg), demonstrating that this mutagenic epoxide metabolite circulates to extrahepatic target organs following ACN administration.

引用

页码：25 / 30

页数：6

共 12 条

[1] Comparative Toxicokinetics of 2,3-C-14- and 1-C-14-acrylonitrile in the Rat [J].