SYNTHESIS AND SPECTROSCOPIC PROPERTIES OF C-13- AND N-15-LABELED TERT-BUTOXYCARBONYLGLYCINES

被引：12

作者：

GREHN, L ^{[1
]}

PEHK, T ^{[1
]}

RAGNARSSON, U ^{[1
]}

机构：

[1] ESTONIAN ACAD SCI,INST CHEM PHYS & BIOPHYS,TALLINN 200001,ESTONIA

来源：

ACTA CHEMICA SCANDINAVICA | 1993年 / 47卷 / 11期

关键词：

D O I：

10.3891/acta.chem.scand.47-1107

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three C-13-labelled bromoacetates have been reacted both with N-15-labelled and with unlabelled di-tert-butyl imidodicarbonate and the intermediates selectively deprotected to give the corresponding isotopomeric Boc-glycines for application in peptide synthesis. The products were characterized by H-1, C-13 and N-15 NMR and FT-IR spectroscopy. Isotope effects on chemical shifts and IR spectra for this set of compounds are tabulated. In addition, from three isotopomers N-15-labelled amides were also prepared.

引用

页码：1107 / 1111

页数：5

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