EFFECTS OF BILIARY CANNULATION AND BUTHIONINE SULFOXIMINE PRETREATMENT ON THE NEPHROTOXICITY OF PARA-AMINOPHENOL IN THE FISCHER-344 RAT

被引：61

作者：

GARTLAND, KPR

EASON, CT

BONNER, FW

NICHOLSON, JK

机构：

[1] UNIV LONDON,BIRKBECK COLL,DEPT CHEM,GORDON HOUSE,29 GORDON SQ,LONDON WC1H OPP,ENGLAND

[2] STERLING WINTHROP RES CTR,DEPT TOXICOL,ALNWICK NE66 2JH,NORTHD,ENGLAND

来源：

ARCHIVES OF TOXICOLOGY | 1990年 / 64卷 / 01期

关键词：

!sup]1[!/sup] H-NMR urinalysis; Aminoaciduria; biliary cannulation; Buthionine sulphoximine; Glutathione; Glycosuria; Lactic aciduria; Nephrotoxicity; p-Aminophenol; Urinary enzymes;

D O I：

10.1007/BF01973371

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The effects of a glutathione depletor, buthionine sulphoximine (BSO) and biliary cannulation on the nephrotoxicity of p-aminophenol (PAP) have been investigated in the F344 rat. Preatment with BSO completely protected against the nephrotoxicity of a 50 mg/kg dose of PAP, assessed by clinical chemistry, renal histopathology, and1 H-NMR urinalysis. Biliary cannulation partially protects against nephrotoxicity induced by 100 mg/kg PAP. These data suggest that the nephrotoxicity of PAP may be due in part to the formation of a proximate toxic metabolite in the liver which is excreted in the bile, subsequently reabsorbed and transported via the systemic circulation to the kidney where the toxic effects occur. © 1990 Springer-Verlag.

引用

页码：14 / 25

页数：12

共 53 条

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