CRYSTAL-STRUCTURES OF STREPTOMYCES SUBTILISIN INHIBITOR AND ITS COMPLEX WITH SUBTILISIN BPN

被引：85

作者：

MITSUI, Y

SATOW, Y

WATANABE, Y

HIRONO, S

IITAKA, Y

机构：

[1] Faculti of Pharmaceutical Sciences, University of Tokyo, Hongo

[2] Laboratory of Molecular Biology, National Institute of Health, Bethesda

来源：

NATURE | 1979年 / 277卷 / 5696期

关键词：

D O I：

10.1038/277447a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Crystal structure of a microbial protein proteinase inhibitor SSI (Streptomyces subtilisin inhibitor) and its complex with subtilisin BPN' were solved at 2.6 [~amp]angst; and 4.3 [~amp]angst; resolution respectively. The mode of binding to the proteinase of SSI is compared with that of bovine pancreatic trypsin inhibitor, soybean trypsin inhibitor and the substrates. Stereochemical considerations for the possible evolutionary relationship between SSI and pancreatic secretory trypsin inhibitor are presented. © 1979 Nature Publishing Group.

引用

页码：447 / 452

页数：6

共 50 条

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