DIHYDRALAZINE AND CATECHOLAMINE-SYNTHESIZING ENZYMES IN SPONTANEOUS HYPERTENSION

被引：10

作者：

DENOROY, L

RENAUD, B

VINCENT, M

SACQUET, J

SASSARD, J

机构：

[1] UNIV CLAUDE BERNARD, FAC PHARM, DEPT PHYSIOL & PHARMACOL CLIN, F-69008 LYON, FRANCE

[2] UNIV CLAUDE BERNARD, FAC MED, PHYSIOL LAB, F-69008 LYON, FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 58卷 / 02期

关键词：

Catecholamine synthesizing enzymes; Dihydralazine; Medulla oblongata; Spontaneous hypertension;

D O I：

10.1016/0014-2999(79)90014-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Dihydralazine treatment which lowered blood pressure in young rats from the Lyon Hypertensive Strain (LHS) did not change phenylethanolamine-N-methyltransferase (PNMT) activity, but decreased tyrosine hydroxylase and dopamine-.beta.-hydroxylase activities in the C2 medullary region. The increase in PNMT activity, previously described for this strain, is not a consequence of the developing hypertension and hypotensive treatment could inactivate some catecholaminergic neurons of the medulla oblongata.

引用

页码：207 / 210

页数：4

共 10 条

[1] BRAIN AMINES AND MODELS OF EXPERIMENTAL HYPERTENSION
CHALMERS, JP
[J]. CIRCULATION RESEARCH, 1975, 36 (04) : 469 - 480
[2] DEJONG W, 1979, NERVOUS SYSTEM HYPER, P165
[3] LOWRY OH, 1951, J BIOL CHEM, V193, P265
[4] MOLINOFF PB, 1971, J PHARMACOL EXP THER, V178, P425
[5] RAPID + SIMPLE RADIOASSAY FOR TYROSINE HYDROXYLASE ACTIVITY
NAGATSU, T
UDENFRIEND, S
LEVITT, M
[J]. ANALYTICAL BIOCHEMISTRY, 1964, 9 (01) : 122 - &
[6] ISOLATED REMOVAL OF HYPOTHALAMIC OR OTHER BRAIN NUCLEI OF RAT
PALKOVITS, M
[J]. BRAIN RESEARCH, 1973, 59 (SEP14) : 449 - 450
[7] REIS DJ, 1979, NERVOUS SYSTEM HYPER, P147
[8] EARLY INCREASE IN PHENYLETHANOLAMINE-N-METHYLTRANSFERASE ACTIVITY IN A NEW STRAIN OF SPONTANEOUSLY HYPERTENSIVE RATS
RENAUD, B
FOURNIERE, S
DENOROY, L
VINCENT, M
PUJOL, JF
SASSARD, J
[J]. BRAIN RESEARCH, 1978, 159 (01) : 149 - 159
[9] SAAVEDRA JM, 1976, SCIENCE, V191, P483
[10] VINCENT M, JAP CIRC J

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