A 2ND-GENERATION LINKAGE MAP OF THE HUMAN GENOME

被引：1885

作者：

WEISSENBACH, J

GYAPAY, G

DIB, C

VIGNAL, A

MORISSETTE, J

MILLASSEAU, P

VAYSSEIX, G

LATHROP, M

机构：

[1] INST PASTEUR,UNITE GENET MOLEC HUMAINE,CNRS,URA 1445,F-75724 PARIS,FRANCE

[2] CHU LAVAL,CTR ETUD POLYMORPHISME HUMAIN,QUEBEC CITY G1V 4G2,QUEBEC,CANADA

[3] CHU LAVAL,RESEAU MED GENET,QUEBEC CITY G1V 4G2,QUEBEC,CANADA

[4] INSERM,U358,F-75010 PARIS,FRANCE

来源：

NATURE | 1992年 / 359卷 / 6398期

关键词：

D O I：

10.1038/359794a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A linkage map of the human genome has been constructed based on the segregation analysis of 814 newly characterized polymorphic loci containing short tracts of (C-A)n repeats in a panel of DNAs from eight large families. Statistical linkage analysis placed 813 of the markers into 23 linkage groups corresponding to the 22 autosomes and the X chromosome; 605 show a heterozygosity above 0.7 and 553 could be ordered with odds ratios above 1,000:1. The distance spanned corresponds to approximately 90% of the estimated length of the human genome.

引用

页码：794 / 801

页数：8

共 24 条

[1] SURVEY OF HUMAN AND RAT MICROSATELLITES [J].

BECKMANN, JS ;

WEBER, JL .

GENOMICS, 1992, 12 (04) :627-631

[2]

BISHOP DT, 1990, AM J HUM GENET, V46, P254

[3] MULTIPLEX DNA SEQUENCING [J].

CHURCH, GM ;

KIEFFERHIGGINS, S .

SCIENCE, 1988, 240 (4849) :185-188

[4]

DIETRICH W, 1992, GENETICS, V131, P423

[5] A GENETIC-LINKAGE MAP OF THE HUMAN GENOME [J].

DONISKELLER, H ;

GREEN, P ;

HELMS, C ;

CARTINHOUR, S ;

WEIFFENBACH, B ;

STEPHENS, K ;

KEITH, TP ;

BOWDEN, DW ;

SMITH, DR ;

LANDER, ES ;

BOTSTEIN, D ;

AKOTS, G ;

REDIKER, KS ;

GRAVIUS, T ;

BROWN, VA ;

RISING, MB ;

PARKER, C ;

POWERS, JA ;

WATT, DE ;

KAUFFMAN, ER ;

BRICKER, A ;

PHIPPS, P ;

MULLERKAHLE, H ;

FULTON, TR ;

NG, S ;

SCHUMM, JW ;

BRAMAN, JC ;

KNOWLTON, RG ;

BARKER, DF ;

CROOKS, SM ;

LINCOLN, SE ;

DALY, MJ ;

ABRAHAMSON, J .

CELL, 1987, 51 (02) :319-337

[6]

H/CEPH Collaborative Mapping Group, 1992, SCIENCE, V258, P67

[7] A GENETIC-LINKAGE MAP OF HUMAN CHROMOSOME-20 COMPOSED ENTIRELY OF MICROSATELLITE MARKERS [J].

HAZAN, J ;

DUBAY, C ;

PANKOWIAK, MP ;

BECUWE, N ;

WEISSENBACH, J .

GENOMICS, 1992, 12 (02) :183-189

[8]

LATHROP GM, 1984, AM J HUM GENET, V36, P460

[9]

LATHROP GM, 1991, STAT METH BIOL MED S, V8, P81

[10]

LATHROP GM, 1988, GENOMICS, V2, P157

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