ULTRAVIOLET-IRRADIATION OF THE SKIN ATTENUATES CALCITONIN GENE-RELATED PEPTIDE MESSENGER-RNA EXPRESSION IN RAT DORSAL-ROOT GANGLION-CELLS

被引：18

作者：

GILLARDON, F

MORANO, I

ZIMMERMANN, M

机构：

[1] II. Physiologisches Institut der Universität Heidelberg, Heidelberg

来源：

NEUROSCIENCE LETTERS | 1991年 / 124卷 / 02期

关键词：

CALCITONIN GENE-RELATED PEPTIDE; NEUROPEPTIDE; POLYMERASE CHAIN REACTION; UV ERYTHEMA; PRIMARY SENSORY NEURON;

D O I：

10.1016/0304-3940(91)90080-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Calcitonin gene-related peptide (CGRP) mRNA expression in rat dorsal root ganglion cells was measured by polymerase chain reaction after ultraviolet (UV) irradiation of the skin. The aim was to investigate whether a noninvasive peripheral lesion set by UV irradiation influences neuropeptide gene expression thus possibly contributing to the pathophysiology of the UV erythema. Forty-eight hours after irradiation, when the inflammatory response of the skin was at its maximum, there was a decrease in CGRP mRNA levels to 50% of the control values. The results demonstrate that exposure of the peripheral receptive field to noxious UV radiation affects neuropeptide gene expression in primary sensory neurons.

引用

页码：144 / 147

页数：4

共 18 条

[1] ALTERNATIVE RNA PROCESSING IN CALCITONIN GENE-EXPRESSION GENERATES MESSENGER-RNAS ENCODING DIFFERENT POLYPEPTIDE PRODUCTS [J].