ANTIOXIDANT ACTION OF GUILINGJI IN THE BRAIN OF RATS WITH FECL3-INDUCED EPILEPSY

被引：42

作者：

LIU, JK ^{[1
]}

EDAMATSU, R ^{[1
]}

KABUTO, H ^{[1
]}

MORI, A ^{[1
]}

机构：

[1] OKAYAMA UNIV,SCH MED,INST NEUROBIOL,DEPT NEUROCHEM,2-5-1 SHIKATACHO,OKAYAMA 700,JAPAN

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1990年 / 9卷 / 05期

关键词：

GUILINGJI; THIOBARBITURIC ACID REACTIVE SUBSTANCES (TBARS); SUPEROXIDE DISMUTASE (SOD); FREE RADICALS; ANTIEPILEPTIC; ANTIAGING;

D O I：

10.1016/0891-5849(90)90023-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of Guilingji, an antiaging prescription comprised of traditional Chinese medical herbs and animal components, on the brain level of thiobarbituric acid reactive substances (TBARS) and superoxide dismutase (SOD) activity in the brain of rats with FeCl3-induced epilepsy were examined with fluorophotometry and electron spin resonance (ESR) spectrometry, respectively. The results showed that pretreatment of rats with Guilingji decreased the levels of TBARS in the left cortex, midbrain, and olfactory lobe, and increased the SOD activity in the midbrain an dhypothalamus. These results are the first to demonstrate that Guilingji may possess and antiepileptic effect further to its proposed antiaging action, because decreasing the TBARS elevation and increasing the SOD attenuation in the brain are suggested to be important characteristics of antiepileptic agents. These results suggest that both the proposed antiaging and antiepileptic effects of Guilingji may operate through the mechanism of antioxidation.

引用

页码：451 / 454

页数：4

共 21 条

[1]

Xu, The pharmacological and application of antiaging medicines, (1987)

[2]

Wang, The pharmacological studies of Guilingji, Zhongchengyao Yonjiu, 11, pp. 30-32, (1982)

[3]

Xu, Advances in antiaging actions of complex prescriptions of traditional Chinese medicines, Communications of Pharmacy, 3, pp. 44-48, (1986)

[4]

Liu, Edamatsu, Mori, Scavenging effect of guilingji on free radicals, Neurosciences, (1990)

[5]

Slatter, Free radical mechanisms in tissue injury, Biochem. J., 222, pp. 1-15, (1984)

[6]

Southorn, Powis, Free radicals in medicine, Mayo Clin. Proc., 63, pp. 381-408, (1988)

[7]

Hiramatsu, Kabuto, Mori, Effects of TJ-960 on convulsions and brain 5-hydroxytryptamine in El mice, Recent advances in the pharmacology of KAMPO medicines, pp. 69-73, (1988)

[8]

Hiramatsu, Edamatsu, Kabuto, Mori, Effect of TJ-960 on monoamines, amino acids, lipid peroxides, and superoxide dismutase in brain of aged rats, Recent advances in the pharmacology of KAMPO medicines, pp. 128-135, (1988)

[9]

Hiramatsu, Edamatsu, Kohno, Mori, Scavenging of free radicals by TJ-960, Recent advances in the pharmacology of KAMPO medicines, pp. 120-127, (1988)

[10]

Glowinski, Iversen, Regional studies of catecholamine in the rat brain-I, J. Neuroxhem., 13, pp. 655-669, (1966)

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