CARBOPLATIN AND CYCLOPHOSPHAMIDE SALVAGE THERAPY FOR OVARIAN-CANCER PATIENTS RELAPSING AFTER CISPLATIN COMBINATION CHEMOTHERAPY

被引：39

作者：

VANDERBURG, MEL

HOFF, AM

VANLENT, M

RODENBURG, CJ

VANPUTTEN, WLJ

STOTER, G

机构：

[1] DANIEL DE HOED KLIN,ROTTERDAM CANC INST,DEPT GYNECOL ONCOL,3008 AR ROTTERDAM,NETHERLANDS

[2] DANIEL DE HOED KLIN,ROTTERDAM CANC INST,DEPT BIOSTAT,3008 AE ROTTERDAM,NETHERLANDS

来源：

EUROPEAN JOURNAL OF CANCER | 1991年 / 27卷 / 03期

关键词：

D O I：

10.1016/0277-5379(91)90507-A

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

30 ovarian cancer patients with a relapse after prior cisplatin combination chemotherapy were treated in a phase II study with cyclophosphamide 100 mg/m2 orally on days 1-7 and carboplatin 300 mg/m2 intravenously on day 8. Treatment was well tolerated. The major side-effect was thrombocytopenia. 28 patients were evaluable for response. The response was 5 CRs (18%), 4 PRs (14%) 15 SDs (53%) and 4 PDs (14%), for an overall response rate of 32%. The overall progression-free survival lasted from 2 to 23 months, median 8 months. Overall survival ranged from 2 to 35+ months , median 12 months. Patients with a therapy-free interval of more than 1 year showed a higher response rate (46%) than patients with a shorter therapy-free interval (20%). It is concluded that platinum containing second-line chemotherapy, after treatment that already contained cisplatin, is only warranted to palliate symptoms.

引用

页码：248 / 250

页数：3

共 26 条

[1]

BRUCKNER HW, 1981, CANCER, V47, P2288, DOI 10.1002/1097-0142(19810501)47:9<2288::AID-CNCR2820470931>3.0.CO

[2]

2-3

[3]

COLOMBO N, 1989, 2ND P IGCS M, P130

[4]

COPELAND LJ, 1986, OBSTET GYNECOL, V68, P873

[5]

DECKER DG, 1982, OBSTET GYNECOL, V60, P481

[6]

EDMONSON JH, 1985, CANCER TREAT REP, V69, P1243

[7]

EVANS BD, 1983, CANCER TREAT REP, V67, P997

[8] MOVING-STRIP ABDOMINO-PELVIC RADIOTHERAPY AFTER CIS-PLATINUM-BASED CHEMOTHERAPY AND 2ND-LOOK OPERATION - A FEASIBILITY STUDY IN ADVANCED OVARIAN-CANCER [J].

FALCONE, A ;

CHIARA, S ;

FRANZONE, P ;

VITALE, V ;

SCARPATI, D ;

BRUZZONE, M ;

CARNINO, F ;

CONTE, PF .

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 1988, 11 (01) :16-20

[9] CARBOPLATIN IN COMBINATION THERAPY FOR OVARIAN-CANCER [J].

HUININK, WWT ;

VANDERBURG, MEL ;

VANOOSTEROM, AT ;

NEIJT, JP ;

GEORGE, M ;

GUASTALLA, JP ;

VEENHOF, CHN ;

ROTMENSZ, N ;

DALESIO, O ;

VERMORKEN, JB .

CANCER TREATMENT REVIEWS, 1988, 15 :9-15

[10]

KAVANAGH JJ, 1989, SEMIN ONCOL, V16, P45

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