INHIBITORY EFFECTS OF PLANT SECONDARY METABOLITES ON CYTOTOXIC ACTIVITY OF POLYMORPHONUCLEAR LEUKOCYTES

被引：11

作者：

KINOSHITA, K

MORIKAWA, K

FUJITA, M

NATORI, S

机构：

[1] MEIJI COLL PHARM,YATO CHO,TOKYO 154,JAPAN

[2] NATL INST PUBL HLTH,MINATO KU,TOKYO 108,JAPAN

来源：

PLANTA MEDICA | 1992年 / 58卷 / 02期

关键词：

CYTOTOXICITY; INHIBITION OF TAK-INDUCED ACTIVATION; POLYMORPHONUCLEAR LEUKOCYTES; SECONDARY METABOLITES; QUINONES; ISOQUINOLINE ALKALOIDS; INDOLE ALKALOIDS;

D O I：

10.1055/s-2006-961415

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The inhibitory effects of 151 natural products, representing most of the frequently occurring types, on the cytotoxicity to MM2 tumor cells of polymorphonuclear leucocytes (PMN) induced by TAK, a polysaccharide immunomodulator, were examined. Forty-two compounds inhibited the TAK-induced activation of PMN. Among them, some naturally occurring quinones and various alkaloids (nicotine, Cinchona alkaloids, isoquinoline alkaloids such as cepharanthine, and indole alkaloids such as ajmaline) exhibited potent inhibitory effects. Using the inhibition assay for monitoring, the extracts of Hydrangea Dulcis folium, Scopoliae rhizoma, Cinchona cortex, Magnoliae cortex, Stephania tuber, and Rauwolfia radix were analysed to characterize the active constituents.

引用

页码：137 / 145

页数：9

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