NEURONAL-TYPE NICOTINIC RECEPTORS IN HUMAN NEUROBLASTOMA AND SMALL-CELL LUNG-CARCINOMA CELL-LINES

被引：65

作者：

TARRONI, P ^{[1
]}

RUBBOLI, F ^{[1
]}

CHINI, B ^{[1
]}

ZWART, R ^{[1
]}

OORTGIESEN, M ^{[1
]}

SHER, E ^{[1
]}

CLEMENTI, F ^{[1
]}

机构：

[1] UNIV UTRECHT,TOXICOL RES INST,UTRECHT,NETHERLANDS

来源：

FEBS LETTERS | 1992年 / 312卷 / 01期

关键词：

NICOTINE; RECEPTOR; CLONING; NEUROBLASTOMA; SMALL-CELL LUNG CARCINOMA;

D O I：

10.1016/0014-5793(92)81411-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A beta subunit of the neuronal nicotinic receptor, sharing 88% homology with the rat beta4 subunit, has been cloned from a human neuroblastoma cell line. The gene encoding the human beta4 subunit is expressed in association with the alpha3 gene in neuroblastoma and small-cell lung carcinoma cell lines. Patch-clamp experiments and radioligand binding assays confirm that these neuroendocrine tumor cell lines express functional neuronal nicotinic receptors. We suggest that these receptors might play a crucial role in the control of neurotransmitter and hormone secretion from neurosecretory human tumors.

引用

页码：66 / 70

页数：5

共 25 条

[1] ADENOSINE RECEPTORS LINKED TO ADENYLATE-CYCLASE ACTIVITY IN HUMAN NEURO-BLASTOMA CELLS - MODULATION DURING CELL-DIFFERENTIATION [J].