COMPARISON OF STRUCTURE AND SEQUENCE OF INFLUENZA B/YAMAGATA AND B/BEIJING NEURAMINIDASES SHOWS A CONSERVED HEAD BUT MUCH GREATER VARIABILITY IN THE STALK AND NB PROTEIN

被引：13

作者：

BURMEISTER, WP ^{[1
]}

BAUDIN, F ^{[1
]}

CUSACK, S ^{[1
]}

RUIGROK, RWH ^{[1
]}

机构：

[1] ILL GRENOBLE,EMBL GRENOBLE OUTSTN,BP 156,F-38042 GRENOBLE 9,FRANCE

来源：

VIROLOGY | 1993年 / 192卷 / 02期

关键词：

D O I：

10.1006/viro.1993.1088

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In 1988 the B/Yamagata/16/88 influenza virus appeared, which was antigenically quite different from the other B viruses circulating at that time. Neuraminidase heads of this strain were purified, crystallized, and analyzed by X-ray crystallography and compared with the structure of B/Beijing/1/87 neuraminidase. Only two point mutations could be detected in the “head” of the molecule leading to local rearrangement of amino acid side- chains. The nucleotide sequence, however, revealed significant differences in the stalk region and in the NB protein. © 1993 Academic Press, Inc.

引用

页码：683 / 686

页数：4

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