DIRECTED SYNTHESIS OF PEPTIDES FROM ALPHA-AMINO-ACID ESTERS AT METAL CENTERS

被引：43

作者：

BECK, W

KRAMER, R

机构：

[1] Institut Für Anorganische Chemie, Universität München, W-8000

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1991年 / 30卷 / 11期

关键词：

D O I：

10.1002/anie.199114671

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Peptide esters coordinated in a chelate fashion as in 1 (M = Rh, R = Me) may be extended on the amino ends by reaction with alpha-amino acid esters in the presence of base. In the case of L-leucine methyl ester the resulting tripeptide ester can be cleaved from the metal center with virtually no racemization. The organometallic reagent [{(C5Me5)RhCl2}2] can be recovered.

引用

页码：1467 / 1469

页数：3

共 27 条

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