A TECHNIQUE FOR THE ABSOLUTE QUANTIFICATION OF I-131 RADIOPHARMACEUTICALS USING SPECT

被引：12

作者：

FLEMING, JS

ALAAMER, AA

PERRING, S

机构：

[1] Department of Medical Physics and Nuclear Medicine, Southampton General Hospital, Southampton

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 1993年 / 14卷 / 06期

关键词：

D O I：

10.1097/00006231-199306000-00014

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A technique is described for the quantification of the three-dimensional distribution of I-131 radiopharmaceuticals using single photon emission computed tomography (SPECT). A theoretical discussion of the problems of scatter and septal penetration in I-131 SPECT is presented. The correction of these effects using the geometric mean line source scatter subtraction technique and a distance varying counting sensitivity, is described. The volume and activity of objects in the SPECT dataset were assessed by segmentation using the technique of maximization of interclass variance. The technique has been examined in phantom experiments showing that volumes and activities of objects containing a uniform concentration of activity can be assessed to a precision of 7.3% (1 S.D.) and 0.32 MBq (1 S.D.) respectively. The technique has been successfully applied to patient studies using both I-131-metaiodobenzyl guanidine (MIBG) and lipiodol.

引用

页码：498 / 505

页数：8

共 10 条

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