STEREOSELECTIVE BROMINATION OF BETA-RIBOFURANOSYL AMIDE - ENANTIOSELECTIVE SYNTHESIS OF (+)-HYDANTOCIDIN

被引:52
作者
HARRINGTON, PM [1 ]
JUNG, ME [1 ]
机构
[1] UNIV CALIF LOS ANGELES,DEPT CHEM & BIOCHEM,LOS ANGELES,CA 90024
关键词
D O I
10.1016/S0040-4039(00)77049-3
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The synthesis of hydantocidin, a potent herbicidal natural product, is highlighted by a stereoselective bromination of beta-D-ribofuranosyl amide to give only the alpha-bromo beta-amide and subsequent spirocyclization about the anomeric position with silver cyanate to form the hydantoin moiety.
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页码:5145 / 5148
页数:4
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