ANTIBODIES AGAINST VIRAL NONSTRUCTURAL PROTEINS IN RESPONSE TO INFECTION WITH POLIOVIRUS

被引：12

作者：

EHRENFELD, E

BROWN, D

JIN, XY

SUMMERS, DF

机构：

[1] UNIV CALIF IRVINE,DEPT MOLEC GENET & MICROBIOL,IRVINE,CA 92717

[2] UNIV CALIF IRVINE,DEPT BIOCHEM & MOLEC BIOL,IRVINE,CA 92717

[3] UNIV CALIF IRVINE,DEPT MED,IRVINE,CA 92717

[4] UNIV UTAH,SCH MED,DEPT CELLULAR VIRAL & MOLEC BIOL,SALT LAKE CITY,UT 84132

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 171卷 / 04期

关键词：

D O I：

10.1093/infdis/171.4.845

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sera from recent and past cases of poliomyelitis as well as from healthy subjects vaccinated with live attenuated poliovirus, all contain antibodies to poliovirus nonstructural proteins. Reactivity of these antisera with nonstructural protein antigens present in virus-infected HeLa cells or translated from cDNA transcripts in rabbit reticulocyte lysates was sometimes sensitive to denaturation of the antigens. The finding of antibodies to nonstructural proteins of poliovirus and other viruses should have applications in the development of diagnostic assays for virus infection and may have implications for future vaccine design.

引用

页码：845 / 850

页数：6

共 12 条

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