FAILURE OF CEFOTAXIME IN THE TREATMENT OF MENINGITIS DUE TO RELATIVELY RESISTANT STREPTOCOCCUS-PNEUMONIAE

被引：83

作者：

CATALAN, MJ

FERNANDEZ, JM

VAZQUEZ, A

DESEIJAS, EV

SUAREZ, A

DEQUIROS, JCLB

机构：

[1] UNIV MADRID,HOSP SAN CARLOS,SERV MICROBIOL,MADRID 3,SPAIN

[2] HOSP GEN GREGORIO MARANON,SERV MICROBIOL,MADRID,SPAIN

来源：

CLINICAL INFECTIOUS DISEASES | 1994年 / 18卷 / 05期

关键词：

D O I：

10.1093/clinids/18.5.766

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To our knowledge, we report the first failure of cefotaxime in the treatment of meningitis due to relatively resistant Streptococcus pneumoniae (MICs of penicillin and cefotaxime, 1 mu g/mL). Cure was achieved with a 14-day course of intravenous and intrathecal vancomycin. We recommend that in cases of meningitis caused by strains of S. pneumoniae for which MICs are greater than or equal to 1 mu g/mL, cefotaxime should be used with caution; however, if therapeutic failure is suspected therapy should be changed to intravenous and intrathecal vancomycin.

引用

页码：766 / 769

页数：4

共 27 条

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Aisa M L, 1991, Enferm Infecc Microbiol Clin, V9, P277

[2]

Aristegui J, 1985, An Esp Pediatr, V23, P601

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