ASSISTING SPONTANEITY - THE ROLE OF HSP90 AND SMALL HSPS AS MOLECULAR CHAPERONES

被引：339

作者：

JAKOB, U

BUCHNER, J

机构：

[1] U. Jakob and J. Buchner are, the Institut für Biophysik und Physikalische Biochemie, Universität Regensburg

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 05期

关键词：

D O I：

10.1016/0968-0004(94)90023-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hsp90 and small Hsps are two abundant types of eukaryotic stress protein whose function has remained largely enigmatic. In the cell, Hsp90 exists in a complex (with other Hsps and prolyl isomerases) possibly implicated in interactions with non-native proteins. Recent biochemical analysis of both Hsp90 and small Hsps has revealed that they may act as ATP-independent molecular chaperones involved in protein folding and unfolding events.

引用

页码：205 / 211

页数：7

共 39 条

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