TREATMENT OF SEVERE COLCHICINE OVERDOSE WITH COLCHICINE-SPECIFIC FAB FRAGMENTS

被引：144

作者：

BAUD, FJ

SABOURAUD, A

VICAUT, E

TABOULET, P

LANG, J

BISMUTH, C

ROUZIOUX, JM

SCHERRMANN, JM

机构：

[1] HOP FERNAND WIDAL, INSERM, U26, F-75475 PARIS, FRANCE

[2] HOP FERNAND WIDAL, DEPT BIOPHYS, PARIS, FRANCE

[3] PASTEUR MERIEUX SERUMS & VACCINS, LYON, FRANCE

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 1995年 / 332卷 / 10期

关键词：

D O I：

10.1056/NEJM199503093321004

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

The use of colchicine is limited by its toxicity,1 and colchicine overdose is associated with a high mortality rate. Patients with early hemodynamic collapse due to colchicine overdose have particularly poor prognoses,2,3 and there has been no effective treatment for this complication of severe colchicine intoxication.4 Colchicine binds reversibly to tubulin,5 and colchicine-specific antibodies have been shown to restore the activity of tubulin in vitro.6,7 Colchicine-specific active immunization in rabbits and passive immunization in mice with substoichiometric doses of goat colchicine-specific antibodies and their Fab fragments have been shown to prevent or reverse acute colchicine poisoning.811 These. © 1995, Massachusetts Medical Society. All rights reserved.

引用

页码：642 / 645

页数：4

共 38 条

[1]

Roberts W.N., Liang M.H., Stern SH Colchicine in acute gout.: reassessment of risks and benefits, JAMA, (1987)

[2]

Bismuth C., Gaultier M., Nouv Presse Med, 6, pp. 1625-1629, (1977)

[3]

Sauder P., Kopferschmitt J., Jaeger A., Mantz JM Haemodynamic studies in eight cases of acute colchicine poisoning, Hum Toxicol, 2, pp. 169-173, (1983)

[4]

Ellenhorn M.J., Barceloux D.G., Colchicine overdose and colchicine-containing plant species. In.: Ellenhorn MJ, Barceloux DG, Medical toxicology.: diagnosis and treatment of human poisoning. New York., pp. 1234-1237, (1988)

[5]

Hastie SB Interactions of colchicine with tubulin., 51, pp. 377-401, (1991)

[6]

Wolff J., Capraro H.G., Brossi A., Cook GH Colchicine binding to antibodies, J Biol Chem, 255, pp. 7144-7148, (1980)

[7]

Rouan S.K.E., Otterness I.G., Cunningham A.C., Holden H.E., Rhodes CT Reversal of colchicine-induced mitotic arrest in Chinese hamster cells with a colchicine-specific monoclonal antibody, Am J Pathol, 137, pp. 779-787, (1990)

[8]

Scherrmann J.M., Urtizberea M., Pierson P., Terrien N The effect of colchicine-specific active immunization on colchicine toxicity and disposition in the rabbit, Toxicology, 56, pp. 213-222, (1989)

[9]

Terrien N., Urtizberea M., Scherrmann JM Reversal of advanced colchicine toxicity in mice with goat colchicine-specific antibodies, Toxicol Appl Pharmacol, 104, pp. 504-510, (1990)

[10]

Urtizberea M., Sabouraud A., Cano N., Grandgeorge M., Rouzioux J.M., Scherrmann JM Reversal of murine colchicine toxicity by colchicine-specific Fab fragments, Toxicol Lett, 58, pp. 193-198, (1991)

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