IS SP1 (PREGNANCY SPECIFIC BETA-1-GLYCOPROTEIN) ELEVATED IN CANCER-PATIENTS

被引：6

作者：

ENGVALL, E

YONEMOTO, RH

机构：

[1] CITY HOPE NATL MED CTR, DIV IMMUNOL, DUARTE, CA 91010 USA

[2] CITY HOPE NATL MED CTR, DEPT GEN & ONCOL SURG, DUARTE, CA 91010 USA

来源：

INTERNATIONAL JOURNAL OF CANCER | 1979年 / 24卷 / 06期

关键词：

D O I：

10.1002/ijc.2910240610

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pregnancy-specific .beta.1-glycoprotein, SP1, was measured in serum by competitive double antibody radioimmunoassay. Very low levels of SP1 or SP1-like activity were found in only 2 of 85 sera from patients with cancer of the digestive tract, breast cancer, melanoma and sarcoma, in 2 of 11 sera from patients with infectious diseases, and in none of 15 sera from nonpregnant healthy individuals. SP1 thus does not seem to be ectopically produced in vivo by the types of cancer studied, but is probably highly specific for the normal and malignant trophoblast.

引用

页码：759 / 761

页数：3

共 14 条

[1] PREGNANCY BETA-1 GLYCOPROTEIN AND CHORIONIC-GONADOTROPIN IN SERUM OF PATIENTS WITH TROPHOBLASTIC AND NON-TROPHOBLASTIC TUMORS [J].