VASOACTIVE-INTESTINAL-PEPTIDE STIMULATES CHICK PINEAL MELATONIN PRODUCTION AND INTERACTS WITH OTHER STIMULATORY AND INHIBITORY AGENTS BUT DOES NOT SHOW ALPHA-1-ADRENERGIC POTENTIATION

被引：14

作者：

ZATZ, M ^{[1
]}

KASPER, G ^{[1
]}

MARQUEZ, CR ^{[1
]}

机构：

[1] BLAIR HIGH SCH,SENIOR SCI PROGRAM 1989,SILVER SPRING,MD

来源：

JOURNAL OF NEUROCHEMISTRY | 1990年 / 55卷 / 04期

关键词：

Chick pineal; Melatonin production; Vasoactive intestinal peptide; α [!sub]1[!/sub]‐Adrenergic receptors;

D O I：

10.1111/j.1471-4159.1990.tb03118.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract: Vasoactive intestinal peptide (VIP) is known to mimic the effects of β‐adrenergic receptor stimulation in the rat pineal, including marked potentiation by α1‐adrenergic receptor stimulation, and to cause increased melatonin synthesis. In contrast, the chick pineal does not respond to β‐adrenergic stimulation, and melatonin synthesis is inhibited by norepinephrine via an α2‐adrenergic receptor. The present experiments show that chick pineal cells in primary culture do, however, respond to VIP with increased melatonin production. The effect of VIP was inhibited by addition of norepinephrine or of nitrendipine or by exposing the cells to “unexpected” white light. Stimulation by VIP was enhanced by addition of forskolin or Bay K 8644 but not by α1adrenergic receptor stimulation. Although stimulation by VIP appears similar in the chick pineal to that seen in the rat pineal and other systems, “dual‐receptor regulation,” at least with α1‐adrenergic receptors, appears to be absent. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：1149 / 1153

页数：5

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