THE INFLUENCE OF ALKYL-AZONES ON THE ORDERING OF THE LAMELLAE IN HUMAN STRATUM-CORNEUM

被引：39

作者：

BOUWSTRA, JA

GOORIS, GS

BRUSSEE, J

SALOMONSDEVRIES, MA

BRAS, W

机构：

[1] DARESBURY SYNCHROTRON RADIAT STN,WARRINGTON WA4,ENGLAND

[2] LEIDEN UNIV,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDS

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 79卷 / 2-3期

关键词：

AZONE; LAMELLAR STRUCTURE; SMALL ANGLE X-RAY SCATTERING; STRATUM-CORNEUM;

D O I：

10.1016/0378-5173(92)90105-B

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of a series of alkyl-azones (N-alkylazocycloheptane-2-one) on the structure of human stratum corncum has been studied by small angle X-ray scattering. Treatment with alkyl-azones having alkyl chains greater than six carbons in length resulted in the disordering of the lamellae in the stratum corneum. The results could be correlated with those obtained by thermal analysis. The remaining thermal transition after treatment with longer alkyl chain azones is probably due to the lipids associated with the proteins.

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收藏

页码：141 / 148

页数：8

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