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EFFECT OF AN ESSENTIAL FATTY-ACID DEFICIENCY ON THE PHOSPHOLIPID-COMPOSITION IN ANTERIOR-PITUITARY MEMBRANES

被引：6
作者：
ALESSIO, ML
WANDSCHEER, DE
SOARES, MCF
CLAUSER, H
ENJALBERT, A
KORDON, C
LEGER, CL
机构：
[1] UNIV FED PERNAMBUCO,DEPT FISIOL & FARMACOL,BR-50000 RECIFE,PE,BRAZIL
[2] CTR PAUL BROCA,INSERM,U159,UNITE NEUROENDOCRINOL,F-75014 PARIS,FRANCE
[3] INRA,CTR RECH JOUY EN JOSAS,RECH NUTR STN,F-78352 JOUY EN JOSAS,FRANCE
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 183卷 / 03期
关键词：
D O I：
10.1016/S0006-291X(05)80296-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effects of an essential fatty acid deficient diet were investigated on the phospholipid fatty acids of several membrane fractions of the rat anterior pituitary, the secretion of which is known to be partly dependent on the membrane phospholipidic constituents. In standard dietary conditions, arachidonic acid (20:4n-6) and its elongation product, adrenic acid (22:4n-6), were the two main polyunsaturated fatty acids in all fractions studied. In rats deprived of EFA for 6 weeks after weaning, the levels of both 20:4n-6 and 22:4n-6 were not changed in microsomal + plasma membrane and nuclear fractions, whereas they were decreased in heavy mitochondrial and light mitochondrial fractions. The present data suggest a mechanism of compensation between membrane fractions which may preferentially preserve 20:4n-6 and 22:4n-6 in discrete membrane fractions. © 1992 Academic Press, Inc.
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页码：1047 / 1055
页数：9
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