HIGH-LEVELS OF CIRCULATING SOLUBLE RECEPTORS FOR TUMOR-NECROSIS-FACTOR IN HAIRY-CELL LEUKEMIA AND TYPE-B CHRONIC LYMPHOCYTIC-LEUKEMIA

被引：98

作者：

DIGEL, W

PORZSOLT, F

SCHMID, M

HERRMANN, F

LESSLAUER, W

BROCKHAUS, M

机构：

[1] UNIV FREIBURG,DEPT INTERNAL MED 1,HUGSTETTER STR 55,W-7800 FREIBURG,GERMANY

[2] UNIV ULM,DEPT INTERNAL MED 3,W-7900 ULM,GERMANY

[3] HOFFMANN LA ROCHE AG,CENT RES UNIT,CH-4002 BASEL,SWITZERLAND

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1992年 / 89卷 / 05期

关键词：

B-CELL MALIGNANCIES; SERUM; INTERFERON THERAPY; TUMOR NECROSIS FACTOR BINDING PROTEIN;

D O I：

10.1172/JCI115769

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The presence of soluble tumor necrosis factor (TNF) binding proteins (BP) was investigated in the sera of healthy volunteer blood donors and cancer patients. Two distinct types of TNFBP, types A and B, which are immunologically related to the cellular 75-kD TNF receptor (TNFR) and the cellular 55-kD TNFR, respectively, were assessed by immunoassays using nonblocking anti-receptor antibodies and I-125-recombinant human TNF-alpha. As compared to the titers observed in 25 healthy controls, TNFBP types A and B titers were found to be elevated in almost all sera obtained from patients with underlying malignant disease. The highest amounts of TNFBP were seen in the sera of patients with B cell malignancies including hairy cell leukemia (HCL) and type B chronic lymphocytic leukemia. Treatment of HCL patients with recombinant human interferon-alpha was associated with decrease of circulating TNFBP.

引用

页码：1690 / 1693

页数：4

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