PREPARATIVE SYNTHESES OF OPTICALLY PURE ORTHOSUBSTITUTED BENZHYDROLS BY ASYMMETRIC REDUCTIONS OF THE CORRESPONDING BENZOPHENONES

被引：29

作者：

BROWN, E

LEZE, A

TOUET, J

机构：

[1] Laboratoire de Synthèse Organique (URA 482), Faculté des Sciences, 72017 Le Mans, Avenue Olivier Messiaen

来源：

TETRAHEDRON-ASYMMETRY | 1992年 / 3卷 / 07期

关键词：

D O I：

10.1016/S0957-4166(00)82179-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Lithium aluminium hydride previously treated with 2.5 equivalents of (S)-(+) or (R)-(-)-2 -(2-iso-indolinyl)butan-1-ol 3 (readily available reagents) reduced the five ortho-substituted benzophenones 4-6, 8 and 10 into the corresponding optically active benzhydrols with nearly 100% enantiomeric excesses. Other examples of asymmetric reductions of prochiral benzophenones are given.

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页码：841 / 844

页数：4

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