MODELING LARGE NUCLEIC-ACIDS

被引：17

作者：

MALHOTRA, A ^{[1
]}

GABB, HA ^{[1
]}

HARVEY, SC ^{[1
]}

机构：

[1] UNIV ALABAMA,DEPT BIOCHEM,BIRMINGHAM,AL 35294

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1993年 / 3卷 / 02期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/S0959-440X(05)80159-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During the past year, a variety of methods have been developed with which to investigate the structures of large nucleic acids. Modeling techniques are assisting in the refinement of structures, particularly for large RNAs. Supercoiled DNA plasmids are being investigated using models that mimic the known elastic properties of the molecule. The level of detail in a particular modeling method must be appropriate to the question being posed.

引用

收藏

页码：241 / 246

页数：6

相关论文

共 47 条

[1] TWIST AND WRITHE OF A DNA LOOP CONTAINING INTRINSIC BENDS [J].

BAUER, WR ;

LUND, RA ;

WHITE, JH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (03) :833-837

[2] ENERGETICS OF THE STRAND SEPARATION TRANSITION IN SUPERHELICAL DNA [J].

BENHAM, CJ .

JOURNAL OF MOLECULAR BIOLOGY, 1992, 225 (03) :835-847

[3] THE ROLE OF THE STRESS RESULTANT IN DETERMINING MECHANICAL EQUILIBRIA OF SUPERHELICAL DNA [J].

BENHAM, CJ .

BIOPOLYMERS, 1987, 26 (01) :9-15

[4] A DETAILED MODEL OF THE 3-DIMENSIONAL STRUCTURE OF ESCHERICHIA-COLI 16-S RIBOSOMAL-RNA INSITU IN THE 30-S SUBUNIT [J].

BRIMACOMBE, R ;

ATMADJA, J ;

STIEGE, W ;

SCHULER, D .

JOURNAL OF MOLECULAR BIOLOGY, 1988, 199 (01) :115-136

[5] CRYSTALLOGRAPHIC R-FACTOR REFINEMENT BY MOLECULAR-DYNAMICS [J].

BRUNGER, AT ;

KURIYAN, J ;

KARPLUS, M .

SCIENCE, 1987, 235 (4787) :458-460

[6]

CROTHERS DM, 1992, METHOD ENZYMOL, V212, P3

[7] DEFINITIONS AND NOMENCLATURE OF NUCLEIC-ACID STRUCTURE PARAMETERS [J].

DICKERSON, RE .

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1989, 6 (04) :627-634

[8] THE 3-DIMENSIONAL FOLDING OF RIBOSOMAL-RNA - LOCALIZATION OF A SERIES OF INTRA-RNA CROSS-LINKS IN 23S RNA INDUCED BY TREATMENT OF ESCHERICHIA-COLI 50S RIBOSOMAL-SUBUNITS WITH BIS-(2-CHLOROETHYL)-METHYLAMINE [J].

DORING, T ;

GREUER, B ;

BRIMACOMBE, R .

NUCLEIC ACIDS RESEARCH, 1991, 19 (13) :3517-3524

[9]

FRATINI AV, 1982, J BIOL CHEM, V257, P4686

[10] MOLECULAR MODELING TO PREDICT THE STRUCTURAL AND BIOLOGICAL EFFECTS OF MUTATIONS IN A HIGHLY CONSERVED HISTONE MESSENGER-RNA LOOP SEQUENCE [J].

GABB, HA ;

HARRIS, ME ;

PANDEY, NB ;

MARZLUFF, WF ;

HARVEY, SC .

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1992, 9 (06) :1119-1130

← 1 2 3 4 5 →