MODELING LARGE NUCLEIC-ACIDS

被引：17

作者：

MALHOTRA, A ^{[1
]}

GABB, HA ^{[1
]}

HARVEY, SC ^{[1
]}

机构：

[1] UNIV ALABAMA,DEPT BIOCHEM,BIRMINGHAM,AL 35294

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1993年 / 3卷 / 02期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S0959-440X(05)80159-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During the past year, a variety of methods have been developed with which to investigate the structures of large nucleic acids. Modeling techniques are assisting in the refinement of structures, particularly for large RNAs. Supercoiled DNA plasmids are being investigated using models that mimic the known elastic properties of the molecule. The level of detail in a particular modeling method must be appropriate to the question being posed.

引用

收藏

页码：241 / 246

页数：6

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