HUMAN CILIARY NEUROTROPHIC FACTOR - LOCALIZATION TO THE PROXIMAL REGION OF THE LONG ARM OF CHROMOSOME-11 AND ASSOCIATION WITH CA/GT DINUCLEOTIDE REPEAT

被引：13

作者：

LEV, AA

ROSEN, DR

KOS, C

CLIFFORD, E

LANDES, G

HAUSER, SL

BROWN, RH

机构：

[1] MASSACHUSETTS GEN HOSP, NEUROIMMUNOL UNIT, BOSTON, MA 02114 USA

[2] HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA

[3] IG LABS INC, FRAMINGHAM, MA USA

来源：

GENOMICS | 1993年 / 16卷 / 02期

关键词：

D O I：

10.1006/geno.1993.1226

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Ciliary neurotrophic factor (CNTF) promotes survival and differentiation of several types of sensory, motor, sympathetic, and parasympathetic neurons. We have used the polymerase chain reaction to amplify, clone, and partially sequence CNTF cDNA from human muscle. Using a rodent-human mapping panel and fluorescence in situ hybridization, we have localized a single copy of the gene for human CNTF to the proximal long arm of chromosome 11. We have also identified a polymorphic tandem CA/GT dinucleotide repeat associated with the human CNTF gene. © 1993 Academic Press. All rights reserved.

引用

页码：539 / 541

页数：3

共 14 条

[1]

ARAKAWA Y, 1990, J NEUROSCI, V10, P3507

[2] PURIFICATION OF THE CHICK EYE CILIARY NEURONOTROPHIC FACTOR [J].