TRANSIENT LOCALIZATION OF 5-HT1A RECEPTORS IN HUMAN CEREBELLUM DURING DEVELOPMENT

被引：25

作者：

DELOLMO, E

DIAZ, A

GUIRAOPINEYRO, M

DELARCO, C

PASCUAL, J

PAZOS, A

机构：

[1] UNIV CANTABRIA,FAC MED,DEPT PHYSIOL & PHARMACOL,PHARMACOL UNIT,E-39011 SANTANDER,SPAIN

[2] UNIV GRANADA,DEPT MORPHOL SCI,GRANADA,SPAIN

来源：

NEUROSCIENCE LETTERS | 1994年 / 166卷 / 02期

关键词：

SEROTONIN 5-HT1A RECEPTOR; H-3] 8-OH-DPAT; FETAL HUMAN BRAIN; CEREBELLUM; AUTORADIOGRAPHY;

D O I：

10.1016/0304-3940(94)90472-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The appearance and distribution of 5-HT1A receptors in the human cerebellum during the ontogenetic development was studied in samples from a group of fetal, neonatal and adult cases, by means of quantitative autoradiography and membrane binding. [H-3]8-OH-DPAT was used as a ligand. High densities of 5-HT1A receptors were found during the fetal and neonatal stages over the whole cerebellar cortex, with a slight predominance in the external part, in a band which included the molecular layer. In contrast, the adult cerebellum was nearly devoid of such sites. This finding supports a role for 5-HT1A receptors in the regulation of development in the human cerebellum.

引用

页码：149 / 152

页数：4

共 20 条

[1]

Altman J., 1982, CEREBELLUM NEW VISTA, V47, P8

[2] FETAL HUMAN BRAIN EXHIBITS A PRENATAL PEAK IN THE DENSITY OF SEROTONIN 5-HT1A RECEPTORS [J].