4-HELIX BUNDLE GROWTH-FACTORS AND THEIR RECEPTORS - PROTEIN-PROTEIN INTERACTIONS

被引：73

作者：

MOTT, HR

CAMPBELL, ID

机构：

[1] HR Mott and ID Campbell, Department of Biochemistry, Oxford, OX1 3QU, South Parks Road

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1995年 / 5卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0959-440X(95)80016-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many growth factors and cytokines promote receptor clustering on binding, At least three different protein-protein interaction sites are involved: cytokine-receptor I, cytokine-receptor II and receptor I-receptor II. Although structural data on these complexes are limited, recent structural and mutagenesis studies of the four-helix bundle class of cytokines are clarifying the nature of the complexes formed.

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收藏

页码：114 / 121

页数：8

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