AXIAL SKELETON HOMEOSIS AND FORELIMB MALFORMATIONS IN HOXD-11 MUTANT MICE

被引：108

作者：

FAVIER, B

LEMEUR, M

CHAMBON, P

DOLLE, P

机构：

[1] Inst. Genet. Biol. Molec. et Cell., Université Louis Pasteur, Collège de France, C.U. de Strasbourg

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 01期

关键词：

D O I：

10.1073/pnas.92.1.310

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Hoxd-11 gene was disrupted by homologous recombination in embryonic stem cells. We found that Hoxd-11(-/-) mutant mice are viable and display homeotic transformations of their sacral vertebrae, while their forelimbs present abnormalities of some metacarpals and of the first row of carpal bones. These results are discussed in the light of current models of tetrapod axial skeleton and limb patterning.

引用

页码：310 / 314

页数：5

共 18 条

[1] DAVIS AP, 1994, DEVELOPMENT, V120, P2187
[2] HOX-4 GENES AND THE MORPHOGENESIS OF MAMMALIAN GENITALIA
DOLLE, P
IZPISUABELMONTE, JC
BROWN, JM
TICKLE, C
DUBOULE, D
[J]. GENES & DEVELOPMENT, 1991, 5 (10) : 1767 - 1776
[3] DISRUPTION OF THE HOXD-13 GENE INDUCES LOCALIZED HETEROCHRONY LEADING TO MICE WITH NEOTENIC LIMBS
DOLLE, P
DIERICH, A
LEMEUR, M
SCHIMMANG, T
SCHUHBAUR, B
CHAMBON, P
DUBOULE, D
[J]. CELL, 1993, 75 (03) : 431 - 441
[4] LOCAL ALTERATIONS OF KROX-20 AND HOX GENE-EXPRESSION IN THE HINDBRAIN SUGGEST LACK OF RHOMBOMERES-4 AND RHOMBOMERE-5 IN HOMOZYGOTE NULL HOXA-1 (HOX-1.6) MUTANT EMBRYOS
DOLLE, P
LUFKIN, T
KRUMLAUF, R
MARK, M
DUBOULE, D
CHAMBON, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (16) : 7666 - 7670
[5] COORDINATE EXPRESSION OF THE MURINE HOX-5 COMPLEX HOMOEOBOX-CONTAINING GENES DURING LIMB PATTERN-FORMATION
DOLLE, P
IZPISUABELMONTE, JC
FALKENSTEIN, H
RENUCCI, A
DUBOULE, D
[J]. NATURE, 1989, 342 (6251) : 767 - 772
[6] THE VERTEBRATE LIMB - A MODEL SYSTEM TO STUDY THE HOX HOM GENE NETWORK DURING DEVELOPMENT AND EVOLUTION
DUBOULE, D
[J]. BIOESSAYS, 1992, 14 (06) : 375 - 384
[7] Duboule D., 1993, ADV DEV BIOCH, V2, P57
[8] THE ESTABLISHMENT OF MURINE HOX-1 EXPRESSION DOMAINS DURING PATTERNING OF THE LIMB
HAACK, H
GRUSS, P
[J]. DEVELOPMENTAL BIOLOGY, 1993, 157 (02) : 410 - 422
[9] HOLMGREN NILS, 1952, ACTA ZOOL [STOCKHOLM], V33, P1
[10] MURINE GENES RELATED TO THE DROSOPHILA ABDB HOMEOTIC GENE ARE SEQUENTIALLY EXPRESSED DURING DEVELOPMENT OF THE POSTERIOR PART OF THE BODY
IZPISUABELMONTE, JC
FALKENSTEIN, H
DOLLE, P
RENUCCI, A
DUBOULE, D
[J]. EMBO JOURNAL, 1991, 10 (08) : 2279 - 2289

← 1 2 →