2ND-GENERATION BENZODIAZEPINE CCK-B ANTAGONISTS - DEVELOPMENT OF SUBNANOMOLAR ANALOGS WITH SELECTIVITY AND WATER SOLUBILITY

被引：40

作者：

BOCK, MG

DIPARDO, RM

MELLIN, EC

NEWTON, RC

VEBER, DF

FREEDMAN, SB

SMITH, AJ

PATEL, S

KEMP, JA

MARSHALL, GR

FLETCHER, AE

CHAPMAN, KL

ANDERSON, PS

FREIDINGER, RM

机构：

[1] MERCK SHARP & DOHME LTD,DEPT BIOCHEM,W POINT,PA 19486

[2] NEUROSCI RES CTR,HARLOW CM20 2QR,ESSEX,ENGLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 37卷 / 06期

关键词：

D O I：

10.1021/jm00032a003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：722 / 724

页数：3

共 30 条

[1]

ALBERSSCHONBERG G, 1985, PEPTIDES STRUCTURE F, P565

[2] A SINGLE AMINO-ACID OF THE CHOLECYSTOKININ-B GASTRIN RECEPTOR DETERMINES SPECIFICITY FOR NONPEPTIDE ANTAGONISTS [J].

BEINBORN, M ;

LEE, YM ;

MCBRIDE, EW ;

QUINN, SM ;

KOPIN, AS .

NATURE, 1993, 362 (6418) :348-350

[3]

BOCK M G, 1991, Drugs of the Future, V16, P631

[4] AN EXPEDIENT SYNTHESIS OF 3-AMINO-1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE [J].

BOCK, MG ;

DIPARDO, RM ;

EVANS, BE ;

RITTLE, KE ;

VEBER, DF ;

FREIDINGER, RM .

TETRAHEDRON LETTERS, 1987, 28 (09) :939-942

[5] BENZOLACTAMS AS NONPEPTIDE CHOLECYSTOKININ RECEPTOR LIGANDS [J].

BOCK, MG ;

DIPARDO, RM ;

VEBER, DF ;

CHANG, RSL ;

LOTTI, VJ ;

FREEDMAN, SB ;

FREIDINGER, RM .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (05) :871-874

[6] DEVELOPMENT OF 1,4-BENZODIAZEPINE CHOLECYSTOKININ TYPE-B ANTAGONISTS [J].

BOCK, MG ;

DIPARDO, RM ;

EVANS, BE ;

RITTLE, KE ;

WHITTER, WL ;

GARSKY, VM ;

GILBERT, KF ;

LEIGHTON, JL ;

CARSON, KL ;

MELLIN, EC ;

VEBER, DF ;

CHANG, RSL ;

LOTTI, VJ ;

FREEDMAN, SB ;

SMITH, AJ ;

PATEL, S ;

ANDERSON, PS ;

FREIDINGER, RM .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (26) :4276-4292

[7] SYNTHESIS AND RESOLUTION OF 3-AMINO-1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONES [J].

BOCK, MG ;

DIPARDO, RM ;

EVANS, BE ;

RITTLE, KE ;

VEBER, DF ;

FREIDINGER, RM ;

HIRSHFIELD, J ;

SPRINGER, JP .

JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (15) :3232-3239

[8] BENZODIAZEPINE GASTRIN AND BRAIN CHOLECYSTOKININ RECEPTOR LIGANDS - L-365,260 [J].

BOCK, MG ;

DIPARDO, RM ;

EVANS, BE ;

RITTLE, KE ;

WHITTER, WL ;

VEBER, DF ;

ANDERSON, PS ;

FREIDINGER, RM .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (01) :13-16

[9] EFFECTS OF CHOLECYSTOKININ AND RELATED PEPTIDES ON NEURONAL-ACTIVITY IN THE VENTROMEDIAL NUCLEUS OF THE RAT HYPOTHALAMUS [J].

BODEN, P ;

HILL, RG .

BRITISH JOURNAL OF PHARMACOLOGY, 1988, 94 (01) :246-252

[10]

Bradwejn J., 1992, Society for Neuroscience Abstracts, V18, P763

← 1 2 3 →