A novel partner for the GTP-bound forms of rho and rac

被引：150

作者：

Madaule, P ^{[1
]}

Furuyashiki, T ^{[1
]}

Reid, T ^{[1
]}

Ishizaki, T ^{[1
]}

Watanabe, G ^{[1
]}

Morii, N ^{[1
]}

Narumiya, S ^{[1
]}

机构：

[1] KYOTO UNIV,FAC MED,DEPT PHARMACOL 2,SAKYO KU,KYOTO 606,JAPAN

来源：

FEBS LETTERS | 1995年 / 377卷 / 02期

基金：

日本学术振兴会;

关键词：

signal transduction; small GTP-binding protein; two hybrid system; coiled-coil; zinc finger; pleckstrin homology;

D O I：

10.1016/0014-5793(95)01351-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using the yeast two hybrid system and overlay assays me identified a putative rholrac effector, citron, which interacts with the GTP-bound forms of rho and rac1, but not with cdc42. Extensive homologies to known proteins were not observed. This 183 kDa protein contains a C6H2 zinc finger, a PH domain, and a long coiled-coil forming region including 4 leucine zippers and the rholrac binding site, We recently identified three others putative rho effecters characterized by a common rho binding motif. Citron does not share this motif and displays a distinctive protein organization, thus defining a separate class of rho partners.

引用

页码：243 / 248

页数：6

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