SPECIES-DIFFERENCES IN THE HEPATOTOXICITY OF PARACETAMOL ARE DUE TO DIFFERENCES IN THE RATE OF CONVERSION TO ITS CYTOTOXIC METABOLITE

被引:78
作者
TEE, LBG [1 ]
DAVIES, DS [1 ]
SEDDON, CE [1 ]
BOOBIS, AR [1 ]
机构
[1] ROYAL POSTGRAD MED SCH,DEPT PHARMACOL & TOXICOL,DUCANE RD,LONDON W12 0HS,ENGLAND
关键词
D O I
10.1016/0006-2952(87)90412-6
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:1041 / 1052
页数:12
相关论文
共 42 条
[1]  
ALBANO E, 1985, MOL PHARMACOL, V28, P306
[2]   ISOLATION AND IDENTIFICATION OF PARACETAMOL METABOLITES [J].
ANDREWS, RS ;
BOND, CC ;
BURNETT, J ;
SAUNDERS, A ;
WATSON, K .
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 1976, 4 :34-39
[3]   ACETAMINOPHEN HEPATOTOXICITY [J].
BLACK, M .
ANNUAL REVIEW OF MEDICINE, 1984, 35 :577-593
[4]   PARACETAMOL OXIDATION - SYNTHESIS AND REACTIVITY OF N-ACETYL-P-BENZOQUINONEIMINE [J].
BLAIR, IA ;
BOOBIS, AR ;
DAVIES, DS ;
CRESP, TM .
TETRAHEDRON LETTERS, 1980, 21 (51) :4947-4950
[5]   HUMAN CYTOCHROMES-P-450 [J].
BOOBIS, AR ;
DAVIES, DS .
XENOBIOTICA, 1984, 14 (1-2) :151-185
[6]   FRESHLY ISOLATED HEPATOCYTES AS A MODEL FOR STUDYING THE TOXICITY OF PARACETAMOL [J].
BOOBIS, AR ;
TEE, LBG ;
HAMPDEN, CE ;
DAVIES, DS .
FOOD AND CHEMICAL TOXICOLOGY, 1986, 24 (6-7) :731-736
[7]  
BOOBIS AR, 1985, MICROSOMES DRUG OXID, P361
[8]   N-ACETYL-PARA-BENZOQUINONE IMINE - A CYTOCHROME-P-450-MEDIATED OXIDATION-PRODUCT OF ACETAMINOPHEN [J].
DAHLIN, DC ;
MIWA, GT ;
LU, AYH ;
NELSON, SD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (05) :1327-1331
[9]   ACUTE LIVER NECROSIS FOLLOWING OVERDOSE OF PARACETAMOL [J].
DAVIDSON, DG ;
EASTHAM, WN .
BRITISH MEDICAL JOURNAL, 1966, 2 (5512) :497-&
[10]   SPECIES-DIFFERENCES IN HEPATIC GLUTATHIONE DEPLETION, COVALENT BINDING AND HEPATIC NECROSIS AFTER ACETAMINOPHEN [J].
DAVIS, DC ;
POTTER, WZ ;
JOLLOW, DJ ;
MITCHELL, JR .
LIFE SCIENCES, 1974, 14 (11) :2099-2109