NOSOCOMIAL OUTBREAKS DUE TO AMIKACIN-RESISTANT TOBRAMYCIN-SENSITIVE ACINETOBACTER SPECIES - CORRELATION WITH AMIKACIN USAGE

被引：43

作者：

BUISSON, Y

VANNHIEU, GT

GINOT, L

BOUVET, P

SCHILL, H

DRIOT, L

MEYRAN, M

机构：

[1] UNIV PARIS 06,MICROBIOL MED LAB,F-75230 PARIS 05,FRANCE

[2] INST PASTEUR,SERV ENTEROBACTERIES,F-75724 PARIS 15,FRANCE

[3] HOP INSTRUCT ARMEES VAL DE GRACE,BACTERIOL LAB,F-75230 PARIS 05,FRANCE

来源：

JOURNAL OF HOSPITAL INFECTION | 1990年 / 15卷 / 01期

关键词：

3′-O-aminoglycoside phosphotransferase; Acinetobacter; amikacin resistance; nosocomial outbreak;

D O I：

10.1016/0195-6701(90)90024-I

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Fifty-seven patients in the Val-de-Grâce hospital were infected or colonized with amikacin-resistant, tobramycin-sensitive Acinetobacter spp. between January 1985 and December 1987. This resistance phenotype was attributed to the recently described 3′-O-aminoglycoside phosphotrans-ferase (APH(3′)-VI), on the basis of substrate profile and DNA-DNA hybridization, and was mainly encountered in various biotypes of A. baumannii isolated from patients. It was also encountered in saprophytic A. johnsonii isolates from the hands of 11 healthy workers among the medical staff, which provided evidence for the dissemination of an epidemic gene among different biotypes and species of Acinetobacter. A retrospective epidemiological survey showed a significant correlation between amikacin consumption and case incidence in the wards where cross-infection had occurred. © 1990.

引用

页码：83 / 93

页数：11

共 14 条

[1] ACINETOBACTER-CALCOACETICUS OUTBREAK ASSOCIATED WITH PERITONEAL-DIALYSIS [J].