INTERLEUKIN-1 AFFECTS THE BEHAVIORAL DESPAIR RESPONSE IN RATS BY AN INDIRECT MECHANISM WHICH REQUIRES ENDOGENOUS CRF

被引：41

作者：

DELCERRO, S ^{[1
]}

BORRELL, J ^{[1
]}

机构：

[1] CSIC, CAJAL INST, DEPT PSYCHOBIOL, MADRID 6, SPAIN

来源：

BRAIN RESEARCH | 1990年 / 528卷 / 01期

关键词：

Anti-corticotropin-releasing factor; Behavioral despair; Corticotropin-releasing factor; Interleukin-1;

D O I：

10.1016/0006-8993(90)90212-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Interleukin-1 (IL-1) administered intracerebroventricularly (i.c.v.) to rats significantly reduces the level of immobility in animals forced to swim in a confined space. Immunoneutralization of endogenous CRF (corticotropin-releasing factor) by i.c.v. administration of CRF-antiserum prevents the IL-1-induced sinking in rats. This shows that the release of cerebral CRF, probably from the hypothalamus, may mediate the behavioral effect promoted by IL-1. Taken together our results suggest the existence of a complex interface between immune, neuroendocrine and behavioral regulation. © 1990.

引用

页码：162 / 164

页数：3

共 25 条

[1]

Ader R., 1981, PSYCHONEUROIMMUNOLOG, V1st ed.

[2]

ARYA SK, 1984, J IMMUNOL, V133, P273

[3] CORTICOTROPIN-RELEASING FACTOR PRODUCING NEURONS IN THE RAT ACTIVATED BY INTERLEUKIN-1 [J].